Bacteriophytochrome-derived near-infrared fluorescent proteins (NIR FPs) provide deep tissue penetration, low autofluorescence, and endogenous biliverdin compatibility, enabling non-invasive visualization of viral processes in living systems.
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bacteriophytochrome-derived near-infrared fluorescent proteins
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NIR FPs
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These NIR FP reporters support real-time tracking of infection dynamics and host-virus interactions and are described as powering diagnostic platforms including reporter viruses, CRISPR-based assays, and nanotechnology-enhanced biosensors.
The review identifies brightness and photostability limits and the need for broader translational validation as remaining challenges for bacteriophytochrome-derived NIR FP systems.
The review states that integration of NIR FP systems with photoacoustic tomography and PET extends translational utility.
Bacteriophytochrome-derived near-infrared fluorescent proteins are described as providing deep tissue penetration, low autofluorescence, and endogenous biliverdin compatibility for non-invasive visualization in living systems.