First-pass extracted concept

bacteriophytochromes

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Bacteriophytochromes are a subfamily of the diverse light responsive phytochrome photoreceptors... both the structural analysis and the functional characterization of diverse naturally occurring bacteriophytochrome systems have unraveled remarkable differences in signaling mechanisms...

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2019Current Opinion in Structural BiologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application rationalesupports2019Source 1DOI PubMed

Ideal absorption characteristics in the therapeutic near-infrared window and biliverdin availability in mammalian tissues have driven progress in re-engineering bacteriophytochromes for diverse applications.

Claim 2mechanistic diversitysupports2019Source 1DOI PubMed

Structural and functional studies of naturally occurring bacteriophytochrome systems have revealed remarkable differences in signaling mechanisms and only partially sampled the family's evolutionary diversity.

Claim 3tool enabling propertysupports2019Source 1DOI PubMed

Bacteriophytochromes preferentially interact with biliverdin IXα as an endogenous cofactor, which has enabled their use in optogenetic tools and fluorescent probe engineering.