Here, we used RNA sequencing to explore the transcriptomic response in the ear skin of wild bank voles infected with B. afzelii.
First-pass extracted concept
bank vole skin transcriptomic response to Borrelia afzelii infection
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Weighted gene co-expression network analysis identified five gene modules correlated positively or negatively with infection status.
Quoted textsource-backed
Weighted gene co-expression network analysis identified five gene modules, which were positively or negatively correlated with infection status.
The pro-inflammatory response in B. afzelii-infected bank vole skin was suppressed relative to responses reported in humans.
Quoted textsource-backed
However, we found that the pro-inflammatory response is suppressed compared to that reported in humans
In ear skin of wild bank voles, B. afzelii infection was associated with 54 differentially expressed genes relative to uninfected animals.
Quoted textsource-backed
We identified 54 differentially expressed genes, of which 37 showed upregulation, and 17 showed downregulation in infected voles compared to uninfected ones.
B. afzelii infection in bank vole ear skin was associated with changes in expression of extracellular-matrix-related genes whose products are bound and colonized by Borrelia.
Quoted textsource-backed
we identified changes in the expression of genes related to the extracellular matrix, whose products are bound and colonized by Borrelia.
Among immunity-related genes, pathways related to B-cell activity and antibody production were particularly upregulated in infected bank vole ear skin.
Quoted textsource-backed
Among immunity-related genes, pathways related to B-cell activity and antibody production were particularly upregulated.
B. afzelii infection in bank vole ear skin was associated with enrichment of pathways related to immune response, extracellular matrix organization, metabolism, energy production, gene expression, and cell cycle regulation.
Quoted textsource-backed
Enrichment analysis revealed numerous biological processes and pathways related to immune response, extracellular matrix organization, metabolism, energy production, gene expression, and cell cycle regulation.