Base editors are identified as a genome editing modality highlighted by the review. The abstract places them among advances expanding therapeutic possibilities beyond gene knockout.
First-pass extracted concept
base editors
Candidate: concept label4 source documents6 linked claims
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What the tool is doing
Evidence Snippets
advances in genome editing technologies, ranging from CRISPR-Cas nucleases to base and prime editors
This review provides an introduction to the state-of-the-art gene editing tools-including ZFNs, TALENs, CRISPR/Cas9 systems, base editors, and prime editors-and evaluates their application in lipid metabolic pathways central to CVD pathogenesis.
Progress in CRISPR tools-CRISPR nucleases, base editors and prime editors-has expanded the toolkit to induce targeted insertions or deletions, nucleotide conversions and a wider array of genetic alterations.
we will highlight recent advances towards the development of novel immunoreceptors, base editors, and cytokines that have achieved intriguing therapeutic potential
Supporting Sources
Linked Claims
Advances in CRISPR-Cas nucleases, base editors, and prime editors are expanding the therapeutic landscape beyond traditional gene knockout approaches.
The review covers state-of-the-art gene editing tool classes including ZFNs, TALENs, CRISPR/Cas9 systems, base editors, and prime editors for applications in lipid metabolic pathways relevant to cardiovascular disease.
Quoted textsource-backed
This review provides an introduction to the state-of-the-art gene editing tools-including ZFNs, TALENs, CRISPR/Cas9 systems, base editors, and prime editors-and evaluates their application in lipid metabolic pathways central to CVD pathogenesis.
Delivery challenges, long-term safety, immune responses, and editing specificity are critical considerations for safe and effective integration of CRISPR technologies into medicine.
AI contributes to refining nuclease-based editing, base editing, and prime editing.
Quoted textsource-backed
We highlight how AI contributes to refining nuclease-based editing, base editing and prime editing.
Variations in editing outcomes across cell types and unintended off-target effects remain substantial hurdles for CRISPR tools.
Quoted textsource-backed
Nevertheless, variations in editing outcomes across cell types and unintended off-target effects still present substantial hurdles.
Recent advances in modular protein-domain-based engineering include novel immunoreceptors, base editors, and cytokines with intriguing therapeutic potential.