First-pass extracted concept

base excision repair

Candidate: concept label1 source documents3 linked claims

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Aliases

BER

Extracted Explainers

What the tool is doing

BER is described as a major pathway for repair of oxidative DNA lesions in mammalian cells.

Source 1DOI PubMed

What problem it solves

It addresses oxidative base damage, abasic sites, and related DNA lesions generated by reactive oxygen species.

Source 1DOI PubMed

What it does not solve

The abstract does not define which oxidative lesions are exclusively handled by BER versus other pathways.

Source 1DOI PubMed

Alternatives

NER is named alongside BER as another pathway relevant to oxidative lesion repair.

Source 1DOI PubMed

Evidence Snippets

This review will focus on DNA repair of oxidative lesions by base excision repair (BER) and nucleotide excision repair (NER).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review1997Journal of Biological ChemistryDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review scope statementsupports1997Source 1DOI PubMed

Reactive oxygen species generated as by-products of cellular metabolism induce multiple forms of DNA damage including base modifications, abasic sites, deoxyribose damage, and single- and double-strand breaks.

Quoted textsource-backed

Reactive oxygen species (ROS) are generated in cells as a by-product of cellular metabolism. ROS react with proteins, lipids, and DNA. DNA base modifications, abasic sites, deoxyribose damage, and single and double strand breaks are all induced following various forms of oxidative stress.

Claim 2review scope statementsupports1997Source 1DOI PubMed

The review emphasizes mammalian BER enzymes that had recently been cloned and characterized.

Quoted textsource-backed

We will focus on the mammalian BER enzymes that have recently been cloned and characterized.

Claim 3review scope statementsupports1997Source 1DOI PubMed

The review focuses on repair of oxidative DNA lesions in mammalian cells by BER and NER, including nuclear and mitochondrial DNA contexts.

Quoted textsource-backed

This review will focus on DNA repair of oxidative lesions by base excision repair (BER) and nucleotide excision repair (NER).