First-pass extracted concept

basolateral amygdala–nucleus accumbens glutamatergic circuit

Candidate: concept label1 source documents3 linked claims

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Aliases

BLA-NAc circuit, BLA-NAc glutamatergic circuit

Extracted Explainers

What the tool is doing

The paper identifies the BLA-NAc glutamatergic circuit as a regulator of sociability whose activity can be manipulated or modulated.

Source 1DOI PubMed

Evidence Snippets

in vivo optogenetic activation of the basolateral amygdala-nucleus accumbens (BLA-NAc) glutamatergic circuit reduced SI and increased social avoidance in mice

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019Journal of Clinical InvestigationDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional effectsupports2019Source 1DOI PubMed

In vivo optogenetic activation of the BLA-NAc glutamatergic circuit reduced social interaction and increased social avoidance in mice.

Quoted textsource-backed

Here we found that in vivo optogenetic activation of the basolateral amygdala-nucleus accumbens (BLA-NAc) glutamatergic circuit reduced SI and increased social avoidance in mice.

Claim 2functional effectsupports2019Source 1DOI PubMed

Optogenetic inhibition of the BLA-NAc circuit markedly increased social interaction in Shank3B-/- mice without affecting social interaction in WT mice.

Quoted textsource-backed

optogenetic inhibition of the BLA-NAc circuit markedly increased SI in the Shank3B-/- mouse, an ASD model with substantial SI impairment, without affecting SI in WT mice

Claim 3mechanistic effectsupports2019Source 1DOI PubMed

2-AG endocannabinoid signaling reduced BLA-NAc glutamatergic activity.

Quoted textsource-backed

we found that 2-arachidonoylglycerol (2-AG) endocannabinoid signaling reduced BLA-NAc glutamatergic activity