Changes in local regulation of BLA excitability underlie behavioral disturbances characteristic of disorders including post-traumatic stress syndrome (PTSD), autism, attention-deficit hyperactivity disorder (ADHD) and stress-induced relapse to drug use... Converging evidence indicates that chronic stress causes BLA principal output neurons to become hyperexcitable.
First-pass extracted concept
Basolateral amygdala stress-induced hyperexcitability
Candidate: concept label1 source documents4 linked claims
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Aliases
BLA hyperexcitability, stress-induced dysfunction of BLA
Evidence Snippets
Supporting Sources
Linked Claims
Changes in local regulation of basolateral amygdala excitability are described as underlying behavioral disturbances associated with PTSD, autism, ADHD, and stress-induced relapse to drug use.
Molecular alterations in local GABAergic circuits and principal glutamatergic output neurons are described as contributors to dysfunctional neuroplasticity and disruption of basolateral amygdala regulatory neurocircuits.
The review concludes that converging evidence indicates chronic stress causes basolateral amygdala principal output neurons to become hyperexcitable.
The review states that changes in basolateral amygdala function identified in animal addiction models help illuminate human brain imaging and behavioral studies by delineating basolateral amygdala mechanisms more precisely.