First-pass extracted concept

BASP1

Candidate: concept label1 source documents4 linked claims

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Aliases

brain acid-soluble protein 1

Extracted Explainers

What the tool is doing

The review abstract describes BASP1 as regulating actin dynamics and presynaptic vesicle cycling at axon terminals, supporting axonal growth, regeneration, and plasticity.

Source 1DOI PubMed

What problem it solves

As a review subject, it helps frame molecular mechanisms relevant to neural injury response and regeneration.

Source 1DOI PubMed

What it does not solve

The abstract does not present BASP1 itself as an engineered construct, delivery system, or reusable assay method.

Source 1DOI PubMed

Alternatives

The review discusses GAP-43 alongside BASP1 as a related molecule with overlapping relevance to axon regeneration.

Source 1DOI PubMed

Evidence Snippets

Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal growth, regeneration, and plasticity.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2020Frontiers in Cell and Developmental BiologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease association summarysupports2020Source 1DOI PubMed

Studies in neurodegenerative diseases report altered expression and phosphorylation profiles of GAP-43 and BASP1.

Quoted textsource-backed

Interestingly, examinations of GAP-43 and BASP1 in neurodegenerative diseases reveal alterations in their expression and phosphorylation profiles.

Claim 2functional role summarysupports2020Source 1DOI PubMed

GAP-43 and BASP1 regulate actin dynamics and presynaptic vesicle cycling at axon terminals and thereby facilitate axonal growth, regeneration, and plasticity.

Quoted textsource-backed

Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal growth, regeneration, and plasticity.

Claim 3regulation summarysupports2020Source 1DOI PubMed

The functions of GAP-43 and BASP1 in axonal growth-related processes depend strongly on expression levels and post-translational modifications such as phosphorylation.

Quoted textsource-backed

These functions highly depend on changes in GAP-43 and BASP1 expression levels and post-translational modifications such as phosphorylation.

Claim 4therapeutic potential summarysupports2020Source 1DOI PubMed

The review explores the therapeutic potential of modulating GAP-43 and BASP1 activities to compensate for neuron loss in neurodegenerative diseases.

Quoted textsource-backed

By discussing GAP-43 and BASP1 in the context of neurodegenerative diseases, we also explore the therapeutic potential of modulating their activities to compensate for neuron loss in neurodegenerative diseases.