The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.
First-pass extracted concept
BDNF as a future drug-development target
Candidate: concept label1 source documents3 linked claims
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Evidence Snippets
Supporting Sources
Linked Claims
BDNF is described as the most prevalent growth factor in the central nervous system and as essential for CNS development and neuronal plasticity.
Quoted textsource-backed
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity.
The review summarizes clinical and preclinical evidence that BDNF is involved in major depressive disorder, schizophrenia, addiction, Rett syndrome, and other psychiatric and neurodevelopmental diseases.
Quoted textsource-backed
Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases.
The review discusses BDNF in the mechanism of action of pharmacological therapies currently used to treat neuropsychiatric diseases, including antidepressants and antipsychotics.
Quoted textsource-backed
In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics.