First-pass extracted concept

bioelectric cell states

Candidate: concept label1 source documents4 linked claims

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Aliases

membrane voltage potential regionalization, resting potential, Vmem

Evidence Snippets

Misexpression in Xenopus of KCNJ2 carrying ATS-associated mutations causes CFAs in the same structures affected in humans, changes the normal pattern of membrane voltage potential regionalization in the developing face and disrupts expression of important craniofacial patterning genes, revealing the endogenous control of craniofacial patterning by bioelectric cell states.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2016The Journal of PhysiologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1developmental mechanismsupports2016Source 1DOI PubMed

Developmentally patterned potassium flux is required for correct resting-potential regionalization and establishment of early gene expression domains in the anterior ectoderm.

Claim 2disease mechanismsupports2016Source 1DOI PubMed

ATS-associated KCNJ2 variants cause craniofacial anomalies in Xenopus and disrupt membrane voltage regionalization in the developing face.

Claim 3mechanistic sufficiencysupports2016Source 1DOI PubMed

Changing ectodermal resting potential is sufficient to cause craniofacial anomalies and this effect is not tied to a specific ion or channel protein.

Claim 4temporal requirementsupports2016Source 1DOI PubMed

Perturbing ectodermal membrane voltage causes craniofacial anomalies only during early neurula stages, whereas late neurulation perturbation does not affect craniofacial development.