First-pass extracted concept

biomolecular condensates

Candidate: concept label4 source documents6 linked claims

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Evidence Snippets

This review aims to systematically compile the principles regulating LLPS... and we will also examine the significance of physiological phase separation and its connection to pathological phase transitions.

Evidence 1Source 1DOI PubMedprovenance

Supported directly by the review title: "Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets".

Evidence 2Source 2DOI PubMedprovenance

Membraneless assemblies known as biomolecular condensates have been reported to play key roles in many cellular functions by compartmentalizing specific proteins and nucleic acids in subcellular environments with distinct properties.

Evidence 3Source 3DOI PubMedprovenance

The supplied web research summary identifies biomolecular condensates as broader terminology overlapping with the review's scope on phase-separated cellular assemblies.

Evidence 4Source 4DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2025Molecular BiomedicineDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 3review2022Nature Reviews Drug DiscoveryDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Source 4review2018Trends in Cell BiologyDOI PubMed

1 evidence snippet 0 linked claims

Linked Claims

Claim 1pathological transitionsupports2026Source 1DOI PubMed

Physiological phase separation is connected to pathological phase transitions including conversion from a liquid to a solid state.

Claim 2regulatory factorssupports2026Source 1DOI PubMed

Physicochemical properties, molecular structures, and post-translational modifications affect condensate formation.

Claim 3review scopesupports2025Source 2DOI PubMed

This review covers biomolecular condensate molecular structure, biological functions, diseases, and therapeutic targets.

Claim 4biological role summarysupports2022Source 3DOI PubMed

Biomolecular condensates play key roles in many cellular functions by compartmentalizing specific proteins and nucleic acids in subcellular environments with distinct properties.

Claim 5mechanism summarysupports2022Source 3DOI PubMed

Biomolecular condensates often form by phase separation that demixes a single-phase system into condensed and dilute phases of particular biomolecules.

Claim 6therapeutic opportunity summarysupports2022Source 3DOI PubMed

Understanding condensate function in normal and aberrant cellular states and mechanisms of condensate formation is revealing novel therapeutic opportunities.