First-pass extracted concept

BLA glutamatergic neurons

Candidate: concept label1 source documents3 linked claims

Jump to explainers Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

BLAGlu neurons

Extracted Explainers

What the tool is doing

The paper identifies BLA glutamatergic neurons as overactive in CIBP and as a manipulable node whose inhibition raises pain thresholds.

Source 1DOI PubMed

Resources required

The abstract supports the need for activity readouts and inhibitory neural-manipulation methods in mice.

Source 1DOI PubMed

What problem it solves

It helps localize CIBP-related brain activity to a specific neuronal population in the basolateral amygdala.

Source 1DOI PubMed

What it does not solve

The abstract does not establish whether these neurons are sufficient to explain all sensory and affective components of pain.

Source 1DOI PubMed

Alternatives

The abstract also implicates upstream PrL glutamatergic neurons projecting to BLA.

Source 1DOI PubMed

Evidence Snippets

c-Fos expression and calcium activity in BLAGlu neurons were significantly elevated in CIBP models.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1activity changesupports2026Source 1DOI PubMed

BLA glutamatergic neurons show elevated c-Fos expression and calcium activity in cancer-induced bone pain models.

Claim 2intervention effectsupports2026Source 1DOI PubMed

Chemogenetic inhibition of BLA glutamatergic neurons reverses overactivation and pain-threshold changes in cancer-induced bone pain mice.

Claim 3intervention effectsupports2026Source 1DOI PubMed

Optogenetic inhibition of BLA glutamatergic neurons or PrL glutamatergic neurons projecting to BLA increases pain thresholds in cancer-induced bone pain mice.