First-pass extracted concept

blood-brain barrier

Candidate: concept label6 source documents6 linked claims

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Aliases

BBB

Evidence Snippets

Treatment failure is largely driven by the Blood-Brain Barrier (BBB), which restricts the delivery of most conventional therapeutics and shields invasive tumor regions from systemic drugs.

Evidence 1Source 1DOI PubMedprovenance

Ultrasound-assisted drug delivery systems (US-DDS) leverage MB/NB cavitation effects to enhance chemotherapeutic agent delivery efficiency, overcome biological barriers, including the blood-brain barrier, and modulate immune responses.

Evidence 2Source 2DOI PubMedprovenance

Neurological gliomas, as the most common and deadly primary brain tumors, face two major therapeutic obstacles: the blockade of the blood-brain barrier (BBB) and high tumor heterogeneity.

Evidence 3Source 3DOI PubMedprovenance

The blood brain barrier (BBB) plays a critically important role in the regulation of central nervous system (CNS) homeostasis, but also represents a major limitation to treatments of brain pathologies.

Evidence 4Source 4DOI PubMedprovenance

These clots, blood cells but also blood derivatives in the perivascular space, destabilize the blood-brain barrier from the brain parenchyma side.

Evidence 5Source 5DOI PubMedprovenance

The review centers on translational brain barrier biology across the blood-brain barrier (BBB), blood-CSF barrier, neurovascular unit (NVU), transport biology, tight junctions, development, and imaging.

Evidence 6Source 6DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 3primary paper2025MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 4primary paper2022MEDDOI PubMed

1 evidence snippet 0 linked claims

Source 5review2019Translational Stroke ResearchDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 6review2011Nature reviews. NeuroscienceDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1disease barriersupports2026Source 1DOI PubMed

In glioblastoma, treatment failure is largely driven by the blood-brain barrier because it restricts delivery of most conventional therapeutics and shields invasive tumor regions from systemic drugs.

Claim 2platform capabilitysupports2026Source 1DOI PubMed

Recent inorganic nanoparticles are designed to cross the blood-brain barrier and target glioblastoma.

Claim 3capabilitysupports2025Source 2DOI PubMed

Ultrasound-assisted drug delivery systems use microbubble or nanobubble cavitation to enhance chemotherapeutic delivery, overcome biological barriers including the blood-brain barrier, and modulate immune responses.

Quoted textsource-backed

Ultrasound-assisted drug delivery systems (US-DDS) leverage MB/NB cavitation effects to enhance chemotherapeutic agent delivery efficiency, overcome biological barriers, including the blood-brain barrier, and modulate immune responses.

Claim 4problem statementsupports2025Source 3DOI PubMed

Gliomas face two major therapeutic obstacles: blood-brain barrier blockade and high tumor heterogeneity.

Claim 5mechanistic summarysupports2019Source 5DOI PubMed

Blood cells and blood derivatives in the perivascular space are proposed to destabilize the blood-brain barrier and weaken the neurovascular unit after IVH/rt-PA-associated clot dissolution.

Claim 6review scopesupports2011Source 6DOI PubMed

This review synthesizes translational research themes in brain barrier biology spanning the blood-brain barrier, blood-cerebrospinal fluid barrier, neurovascular unit, transport biology, tight junctions, development, and imaging.