low-intensity focused ultrasound has been demonstrated in both neuromodulation and blood-brain barrier opening to allow the entry of therapeutic molecules into the central nervous system.
First-pass extracted concept
blood-brain barrier opening
Candidate: concept label7 source documents8 linked claims
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Aliases
BBBO, BBB opening
Evidence Snippets
Beyond lesioning, low-intensity focused ultrasound enables reversible neuromodulation and transient blood-brain barrier opening, facilitating drug and gene delivery in conditions such as Alzheimer's disease and glioblastoma.
Its applications include ablation for movement and psychiatric disorders, blood-brain barrier opening (BBBO) for drug delivery in neuro-oncology and neurodegeneration, and neuromodulation for circuit-based interventions in addiction, mood/anxiety disorders, and chronic pain.
fTUS has been explored for blood-brain barrier opening, facilitating drug delivery for conditions like glioblastoma and Alzheimer's disease.
Focused ultrasound (FUS) combined with microbubbles (MBs) can transiently open the BBB.
Modern technologies allow focusing ultrasound through the human skull for highly focal tissue ablation, clinical neuromodulatory brain stimulation, and targeted focal blood-brain-barrier opening.
FUS with circulating microbubbles is currently the only method for inducing precise, transient, reversible, and noninvasive BBB opening (BBBO).
Supporting Sources
Linked Claims
tFUS applications include intracranial ablation, blood-brain barrier opening for drug delivery, and neuromodulation.
Quoted textsource-backed
Its applications include ablation for movement and psychiatric disorders, blood-brain barrier opening (BBBO) for drug delivery in neuro-oncology and neurodegeneration, and neuromodulation for circuit-based interventions in addiction, mood/anxiety disorders, and chronic pain.
Low-intensity focused ultrasound-facilitated blood-brain barrier opening can facilitate drug and gene delivery in conditions such as Alzheimer's disease and glioblastoma.
Low-intensity focused ultrasound has been demonstrated for neuromodulation and blood-brain barrier opening to allow therapeutic molecules to enter the central nervous system.
Low-intensity focused ultrasound enables reversible neuromodulation and transient blood-brain barrier opening.
Focused transcranial ultrasound stimulation has been explored for blood-brain barrier opening to facilitate drug delivery in glioblastoma and Alzheimer's disease.
Focused ultrasound combined with microbubbles can transiently open the blood-brain barrier.
Focused ultrasound combined with microbubbles opens the blood-brain barrier through cavitation, modulation of tight junction protein expression, and enhanced vesicular transport in endothelial cells.
FUS with circulating microbubbles is currently the only method for precise, transient, reversible, and noninvasive blood-brain barrier opening.
Quoted textsource-backed
FUS with circulating microbubbles is currently the only method for inducing precise, transient, reversible, and noninvasive BBB opening (BBBO).