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First-pass extracted concept

blood transfusion-induced immunomodulation

Candidate: concept label1 source documents5 linked claims
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Aliases

transfusion-induced immunomodulation

Extracted Explainers

What the tool is doing

This term describes immune changes associated with blood transfusion. In the review, those changes are framed as potentially beneficial in graft survival but harmful in cancer recurrence and postoperative infection.

Source 1DOIPubMed

What problem it solves

It gives a common framework for discussing diverse clinical observations linked to transfusion.

Source 1DOIPubMed

What it does not solve

The provided source text does not cleanly resolve which blood component or mechanism is responsible for the effect.

Source 1DOIPubMed

Alternatives

Later literature summarized in the job payload often uses the alternate term transfusion-related immunomodulation (TRIM).

Source 1DOIPubMed

Evidence Snippets

Blood transfusion may result in immunologic changes (immunomodulation) that are beneficial in some patients but harmful in others.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1clinical associationsupports1996Source 1DOIPubMed

Clinical studies have shown a beneficial effect of blood transfusion on graft survival.

Quoted textsource-backed
Clinical studies have shown a beneficial effect of blood transfusion on graft survival [3,4]
Claim 2clinical associationsupports1996Source 1DOIPubMed

Clinical studies have shown an adverse effect of blood transfusion on cancer recurrence.

Quoted textsource-backed
Clinical studies have shown ... an adverse effect on cancer recurrence [5-10]
Claim 3clinical associationsupports1996Source 1DOIPubMed

Clinical studies have shown an adverse effect of blood transfusion on postoperative infection.

Quoted textsource-backed
Clinical studies have shown ... an adverse effect on ... postoperative infection [10-14].
Claim 4review summarysupports1996Source 1DOIPubMed

Blood transfusion may cause immunologic changes that can be beneficial in some patients and harmful in others.

Quoted textsource-backed
Blood transfusion may result in immunologic changes (immunomodulation) that are beneficial in some patients but harmful in others.
Claim 5utilization summarysupports1996Source 1DOIPubMed

Approximately two thirds of perioperative transfusions in the cited dataset were administered by anesthesiologists, and 26% were given inappropriately.

Quoted textsource-backed
Approximately two thirds of 11,000 transfusions [15,16] given perioperatively are administered by anesthesiologists [17], and 26% are given inappropriately [18,19].