Here, we developed a light-inducible strategy to induce BMP4 signaling with precise spatial coordinates in human pluripotent stem cells.
First-pass extracted concept
BMP4 signaling
Candidate: concept label1 source documents5 linked claims
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Supporting Sources
Linked Claims
BMP4-driven mesoderm differentiation relies on tension-dependent induction of WNT and NODAL.
Quoted textsource-backed
and relies on a tension-dependent induction of WNT and NODAL for mesoderm differentiation
Light-controlled BMP4 induces SMAD1-5 phosphorylation and results in amnion differentiation.
Quoted textsource-backed
Light-controlled BMP4 induces SMAD1-5 phosphorylation, resulting in amnion differentiation
In response to BMP4 signaling, nuclear YAP1 represses WNT3 mRNA and regulates induction of the three germ layers.
Quoted textsource-backed
In response to BMP4 signaling, the mechanosensitive transcription factor YAP1 accumulates in the nucleus, where it represses WNT3 mRNA, regulating the induction of the three germ layers.
The paper developed a mathematical model integrating tissue mechanics into morphogen dynamics that quantitatively explains tissue-scale responses to BMP4 signaling.
Quoted textsource-backed
Based on these findings, we developed a mathematical model that integrates tissue mechanics into morphogen dynamics, quantitatively explaining tissue-scale responses to BMP4 signaling.
The paper developed a light-inducible strategy to induce BMP4 signaling with precise spatial coordinates in human pluripotent stem cells.
Quoted textsource-backed
Here, we developed a light-inducible strategy to induce BMP4 signaling with precise spatial coordinates in human pluripotent stem cells.