Our study was undertaken to specify the function of BMPR-1B in steroidogenic enzyme gene expression, testosterone production and reproductive development in male mice.
First-pass extracted concept
BMPR-1B
Candidate: concept label1 source documents4 linked claims
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In adult testicular culture and seminiferous tubule conditioned Leydig cell culture, anti-BMPR-1B reduced testosterone, whereas in normal and Leydig cell conditioned Leydig cell culture it increased testosterone.
Quoted textsource-backed
In adult testicular culture and seminiferous tubule conditioned Leydig cell culture, anti-BMPR-1B reduced testosterone, while in normal and Leydig cell conditioned Leydig cell culture it increased testosterone levels.
In pubertal mice, anti-BMPR-1B reduced gonadotrophin-stimulated seminal vesicle growth.
Quoted textsource-backed
In pubertal mice, anti-BMPR-1B reduced gonadotrophin stimulated seminal vesicle growth.
BMPR-1B modulates steroidogenic enzyme gene expression, testosterone production, and reproductive development in male mouse testis.
Quoted textsource-backed
Our study was undertaken to specify the function of BMPR-1B in steroidogenic enzyme gene expression, testosterone production and reproductive development in male mice... In conclusion, BMPR-1B has specific developmental functions in the autocrine and paracrine regulation of testicular steroidogenic enzyme gene expression and testosterone production in adults and in the development of seminal vesicles during puberty.
In adult mice, anti-BMPR-1B increased testosterone and Hsd3b1 mRNA and decreased Hsd3b6 and Cyp19 mRNA.
Quoted textsource-backed
In adult mice, anti-BMPR-1B increased testosterone and Hsd3b1 but decreased Hsd3b6 and Cyp19 mRNA.