First-pass extracted concept

BNSTprTac1 to POATacr1 male mating circuit

Candidate: concept label1 source documents5 linked claims

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Aliases

BNSTpr^Tac1 -> POA^Tacr1 circuit

Evidence Snippets

We have discovered a developmentally wired neural circuit necessary and sufficient for male mating. This circuit connects chemosensory input to BNSTprTac1 neurons, which innervate POATacr1 neurons that project to centers regulating motor output and reward.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2023MEDDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1behavioral scopesupports2023Source 1DOI PubMed

The identified circuit governs motor displays, drive, and reward aspects of innate male sexual behavior.

Claim 2circuit hierarchysupports2023Source 1DOI PubMed

Epistasis studies place BNSTprTac1 neurons upstream of POATacr1 neurons in the male mating circuit.

Claim 3functional activationsupports2023Source 1DOI PubMed

Experimental activation of POATacr1 neurons triggers mating even in sexually satiated males and is rewarding, eliciting dopamine release and self-stimulation.

Claim 4mechanismsupports2023Source 1DOI PubMed

BNSTprTac1-released substance P following mate recognition potentiates activation of POATacr1 neurons through Tacr1 to initiate mating.

Claim 5necessity and sufficiencysupports2023Source 1DOI PubMed

A developmentally wired neural circuit connecting chemosensory input to BNSTprTac1 neurons and then to POATacr1 neurons is necessary and sufficient for male mating.