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bottom-up techniques

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This Review will focus on a subset of synthetic biology tools known as bottom-up techniques, which use technologies such as optogenetics and chemically induced dimerization to reconstitute cellular behavior in cells.

Evidence 1Source 1DOI PubMedprovenance

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Source 1review2016Science SignalingDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1application scopesupports2016Source 1DOI PubMed

The review discusses use of these systems for time-dependent modulation of protein activity in cellular proliferation and differentiation, reconstitution of phagocytosis, reconstitution of chemotaxis, and regulation of actin reorganization.

Claim 2review scope summarysupports2016Source 1DOI PubMed

Bottom-up synthetic biology techniques such as optogenetics and chemically induced dimerization are used to reconstitute cellular behavior in cells.

Claim 3utility summarysupports2016Source 1DOI PubMed

These bottom-up techniques have been crucial for revealing causal relationships within signaling networks.

Claim 4utility summarysupports2016Source 1DOI PubMed

These techniques have been crucial for identifying the minimal signaling components necessary for a given cellular function.