First-pass extracted concept

branched chain amino acids

Candidate: concept label2 source documents1 linked claims

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Aliases

BCAAs

Evidence Snippets

The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans.

Evidence 1Source 1DOI PubMedprovenance

Of particular interest in relation to extrahepatic tissues are the branched chain amino acids (BCAAs). BCAA levels are increased in the bloodstream of obese humans and in animal models of obesity.

Evidence 2Source 2DOIprovenance

Supporting Sources

Source 1review2019Physiological ReviewsDOI PubMed

1 evidence snippet 0 linked claims

Source 2review2008Journal of Lipid ResearchDOI

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1mechanistic summarysupports2008Source 2DOI

Obesity is associated with increased circulating branched-chain amino acids, and amino acid excess can impair insulin signaling through the mTOR/S6 kinase pathway.

Quoted textsource-backed

BCAA levels are increased in the bloodstream of obese humans and in animal models of obesity... Through their activation of the mTor/S6 kinase pathway, amino acids stimulate serine phosphorylation of IRS1 and blunt insulin signaling.