First-pass extracted concept

bridge helix of Cas12a

Candidate: concept label1 source documents3 linked claims

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Aliases

BH, bridge helix

Evidence Snippets

the loop-to-helical transition and bending of the BH as an allosteric trigger for RNA-DNA hybrid propagation

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanismsupports2026Source 1DOI PubMed

Bridge-helix changes track with coupled remodeling of helix 1 of RuvC motif-II and REC lobe movements needed to accommodate the growing RNA-DNA hybrid.

Quoted textsource-backed

These changes track with the previously reported coupled remodeling of BH and helix 1 of RuvC motif-II as well as the REC lobe movements needed to accommodate the growing hybrid.

Claim 2mechanismsupports2026Source 1DOI PubMed

Bridge-helix transition is essential for loop-to-helical transition of the lid, which opens the RuvC active site pocket for DNA entry and cleavage.

Quoted textsource-backed

The transition of the BH is essential for the loop-to-helical transition of the "lid", which in turn opens the RuvC active site pocket for DNA entry and cleavage.

Claim 3mechanismsupports2026Source 1DOI PubMed

Loop-to-helical transition and bending of the Cas12a bridge helix act as an allosteric trigger for RNA-DNA hybrid propagation.

Quoted textsource-backed

establishes the loop-to-helical transition and bending of the BH as an allosteric trigger for RNA-DNA hybrid propagation