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First-pass extracted concept

c-Fos signal

Candidate: concept label1 source documents5 linked claims
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Aliases

c-fos, Fos signal

Extracted Explainers

What the tool is doing

c-Fos signal is presented as a molecular marker of neural activity. Its level reflects how neural activity is transduced into gene expression.

Source 1DOIPubMed

What problem it solves

It provides a way to read out neural activation and interpret aspects of learning and memory from stimulus-driven gene expression.

Source 1DOIPubMed

What it does not solve

The abstract indicates that Fos signal is not a simple direct proxy for activity because multiple upstream and autoregulatory components shape the readout.

Source 1DOIPubMed

Alternatives

The abstract does not name alternative activity markers.

Source 1DOIPubMed

Evidence Snippets

The immediate early gene c-fos has long been known as a molecular marker of neural activity.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1autoregulationsupports2015Source 1DOIPubMed

Fos protein auto-inhibits and regulates basal Fos expression after translation.

Quoted textsource-backed
Upon translation, the auto-inhibition by Fos protein regulates basal Fos expression.
Claim 2interpretation caveatsupports2015Source 1DOIPubMed

The pattern and valence of external stimuli change Fos signal, so Fos signal reflects learning and memory aspects.

Quoted textsource-backed
The pattern of external stimuli and the valence of the stimulus to the animal change Fos signal, thus the signal reflects learning and memory aspects.
Claim 3molecular marker rolesupports2015Source 1DOIPubMed

c-fos is a molecular marker of neural activity.

Quoted textsource-backed
The immediate early gene c-fos has long been known as a molecular marker of neural activity.
Claim 4signal transduction mechanismsupports2015Source 1DOIPubMed

Neural activity is transduced into Fos signal through intracellular calcium influx via NMDA receptors and L-type voltage-sensitive calcium channels.

Quoted textsource-backed
The neuron's activity is transformed into intracellular calcium influx through NMDA receptors and L-type voltage sensitive calcium channels.
Claim 5transcription requirementsupports2015Source 1DOIPubMed

c-fos transcription requires neural activity strong enough to activate the MAPK signaling pathway.

Quoted textsource-backed
For the transcription of c-fos, neural activity should be strong enough to activate mitogen-activated protein kinase (MAPK) signaling pathway which shows low calcium sensitivity.