First-pass extracted concept

CA1 astrocytic Ca2+ dynamics

Candidate: concept label1 source documents5 linked claims
Live refresh every 5sNext refresh in 5s

Evidence Snippets

hippocampal CA1 astrocytes exhibit de novo Ca2+ dynamics during fear extinction
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1causal perturbationsupports2025Source 1DOIPubMed

Inhibition of CA1 astrocytic Ca2+ dynamics impairs fear extinction, whereas activation of these dynamics facilitates fear extinction.

Quoted textsource-backed
Inhibition of these astrocytic Ca2+ dynamics impairs, while their activation facilitates, fear extinction.
Claim 2mechanistic rolesupports2025Source 1DOIPubMed

Hippocampal CA1 astrocytes exhibit de novo Ca2+ dynamics during fear extinction.

Quoted textsource-backed
Here, we show that hippocampal CA1 astrocytes exhibit de novo Ca2+ dynamics during fear extinction.
Claim 3pathway importancesupports2025Source 1DOIPubMed

A pathway from posterior basal forebrain cholinergic neurons to CA1 astrocytes governs natural fear extinction.

Quoted textsource-backed
our findings demonstrate a previously unrecognized and crucial pathway from pBF cholinergic neurons to CA1 astrocytes that governs natural fear extinction
Claim 4pathway mechanismsupports2025Source 1DOIPubMed

Posterior basal forebrain cholinergic input to hippocampus drives CA1 astrocytic Ca2+ dynamics through activation of nicotinic acetylcholine receptor α4 and α7 subunits.

Quoted textsource-backed
the posterior basal forebrain (pBF) cholinergic input to hippocampus drives CA1 astrocytic Ca2+ dynamics through the activation of α4 and α7 subunits of nicotinic acetylcholine receptors
Claim 5pharmacologic effectsupports2025Source 1DOIPubMed

Donepezil increases CA1 astrocytic Ca2+ dynamics and facilitates fear extinction.

Quoted textsource-backed
Clinically used acetylcholinesterase inhibitor donepezil increases CA1 astrocytic Ca2+ dynamics and facilitates fear extinction.