First-pass extracted concept

cadherin-based adhesion

Candidate: concept label1 source documents3 linked claims

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Extracted Explainers

What the tool is doing

Cadherin-based adhesion is presented as the cell-behavior module coupled to morphogen signaling to generate distinct tissue domains.

Source 1DOI PubMed

Evidence Snippets

By engineering gene expression responsive to artificial morphogens, we observe that coupling morphogen signals with cadherin-based adhesion is sufficient to convert a morphogen gradient into distinct tissue domains.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanism claimsupports2024Source 1DOI PubMed

Morphogen-induced cadherins gather activated cells into a single domain and remove ectopically activated cells.

Claim 2mechanism claimsupports2024Source 1DOI PubMed

Switch-like induction of cadherin-mediated compaction and cell mixing homogenizes activated cells within the morphogen gradient to form a uniformly activated domain with a sharp boundary.

Claim 3sufficiency claimsupports2024Source 1DOI PubMed

Coupling morphogen signals with cadherin-based adhesion is sufficient to convert a morphogen gradient into distinct tissue domains.