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Caenorhabditis elegans as a surrogate model for parasitic nematode biology

Candidate: concept label1 source documents3 linked claims
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Extracted Explainers

What the tool is doing

C. elegans is presented as a surrogate experimental system for analyzing parasitic nematode biology and anthelmintic mode of action. The chapter frames it as a tractable free-living model used to interpret parasite-relevant gene and drug-target function.

Source 1DOI

Resources required

Use of this model depends on access to C. elegans experimental systems and comparative information linking parasite genes or targets to C. elegans homologs or orthologs.

Source 1DOI

What problem it solves

It helps study parasite-relevant biology when direct experimental work in parasitic nematodes is harder, especially for functional characterization and drug-target analysis.

Source 1DOI

What it does not solve

It does not guarantee that gene function or pharmacology will transfer equally well across all parasitic nematodes, especially when phylogenetic distance is greater.

Source 1DOI

Alternatives

The abstract contrasts C. elegans-based experimental approaches with direct screening in parasitic nematodes.

Source 1DOI

Evidence Snippets

In this chapter, the value of C. elegans as a surrogate parasite will be considered.
Evidence 1Source 1DOIprovenance

Supporting Sources

Linked Claims

Claim 1drug target identificationsupports2012Source 1DOI

Examples discussed in the chapter highlight the use of Caenorhabditis elegans as a model system to identify anthelmintic drug targets.

Quoted textsource-backed
The examples highlight the use of C. elegans as a model system to identify anthelmintic drug targets.
Claim 2model scope limitationsupports2012Source 1DOI

The relevance of Caenorhabditis elegans as a model for parasitic nematodes depends on phylogenetic relatedness and may be greater for parasites in the same clade.

Quoted textsource-backed
The phylogenetic relationship between C. elegans and parasitic nematodes suggests that C. elegans may be a preferred model for some parasitic nematodes more than others, being particularly useful for those in the same clade.
Claim 3model system utilitysupports2012Source 1DOI

Caenorhabditis elegans is used as a surrogate model to determine the mode of action of anthelmintics discovered in screens using parasitic nematodes.

Quoted textsource-backed
Until now, new anthelmintics have been discovered through screens using parasitic nematodes. However, their mode of action has often been determined through experimental approaches utilizing the free-living nematode, Caenorhabditis elegans.