Back to first-pass browser

First-pass extracted concept

Caenorhabditis elegans as a surrogate parasite model

Candidate: concept label1 source documents3 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Aliases

C. elegans as a model system, C. elegans as a surrogate parasite

Extracted Explainers

What the tool is doing

C. elegans is presented as a surrogate model used to study parasitic nematode gene function and anthelmintic mode of action. The chapter emphasizes its use for identifying drug targets and interpreting mechanisms.

Source 1DOI

Resources required

Its use is supported by the sequenced C. elegans genome and genomes of parasitic nematodes, enabling homolog and ortholog mapping. Functional studies also require the ability to express parasite genes in C. elegans.

Source 1DOI

What problem it solves

It offers an experimentally tractable system for probing targets and mechanisms that are harder to study directly in parasitic nematodes.

Source 1DOI

What it does not solve

The abstract states that C. elegans is not equally reliable for all parasitic nematodes and may be more useful for species in the same clade.

Source 1DOI

Alternatives

The abstract contrasts C. elegans-based experimental approaches with direct screens using parasitic nematodes.

Source 1DOI

Evidence Snippets

In this chapter, the value of C. elegans as a surrogate parasite will be considered... The examples highlight the use of C. elegans as a model system to identify anthelmintic drug targets.
Evidence 1Source 1DOIprovenance

Supporting Sources

Linked Claims

Claim 1comparative model scopesupports2012Source 1DOI

The usefulness of C. elegans as a surrogate for parasitic nematodes depends on phylogenetic relationship and is likely greater for parasites in the same clade.

Quoted textsource-backed
The phylogenetic relationship between C. elegans and parasitic nematodes suggests that C. elegans may be a preferred model for some parasitic nematodes more than others, being particularly useful for those in the same clade.
Claim 2genomics enabled functional analysissupports2012Source 1DOI

Sequencing of C. elegans and parasitic nematode genomes enabled identification of homologous and orthologous genes and supported expression of parasitic nematode genes in C. elegans for functional characterization.

Quoted textsource-backed
the sequencing of the C. elegans genome followed by the genomes of a number of parasitic nematodes... has enabled the identification of homologous and orthologous genes... and (ii) the expression of parasitic nematode genes in C. elegans to facilitate their functional characterization.
Claim 3model system utilitysupports2012Source 1DOI

Caenorhabditis elegans is used as a surrogate model to determine the mode of action of anthelmintics and to identify anthelmintic drug targets.

Quoted textsource-backed
their mode of action has often been determined through experimental approaches utilizing the free-living nematode, Caenorhabditis elegans... The examples highlight the use of C. elegans as a model system to identify anthelmintic drug targets.