First-pass extracted concept

Calcitriol

Candidate: concept label1 source documents5 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Evidence Snippets

Rats were injected intraperitoneally with calcitriol (1 µg/kg) at 30 min, 24 h and 48 h post-TBI in the calcitriol group.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2017PubMedDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1anti apoptotic effectsupports2017Source 1DOI PubMed

Calcitriol treatment reduced apoptotic cell death after traumatic brain injury in rats.

Claim 2autophagy flux evidencesupports2017Source 1DOI PubMed

Calcitriol treatment was associated with decreased LC3II/LC3I ratio and decreased p62 expression after traumatic brain injury, and chloroquine pretreatment increased LC3II/LC3I ratio in the calcitriol group.

Claim 3expression changesupports2017Source 1DOI PubMed

Calcitriol treatment increased vitamin D receptor protein expression after traumatic brain injury in rats.

Claim 4mechanistic associationsupports2017Source 1DOI PubMed

The protective effects of calcitriol after traumatic brain injury might be associated with restoration of autophagy flux and decreased apoptosis in rat cortex.

Claim 5therapeutic effectsupports2017Source 1DOI PubMed

Calcitriol treatment attenuated neurological deficits after traumatic brain injury in rats.