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First-pass extracted concept

calcium-binding proteins

Candidate: concept label1 source documents3 linked claims
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Aliases

CBPs

Extracted Explainers

What the tool is doing

This review frames calcium-binding proteins as modulators and responders to Ca2+ transients in nervous tissue. They are discussed as part of homeostatic and protective responses during hibernation.

Source 1DOIPubMed

What problem it solves

The concept helps explain how nervous systems may buffer or interpret calcium signals under hypothermic, hypometabolic, and hypoxic stress.

Source 1DOIPubMed

What it does not solve

The abstract does not identify a single engineered or deployable tool based on this class alone.

Source 1DOIPubMed

Alternatives

The review also discusses Ca2+ signaling more broadly and specifically highlights calmodulin and cytoskeletal-associated mechanisms.

Source 1DOIPubMed

Evidence Snippets

Calcium-binding proteins (CBPs) can influence and react to Ca2+ transients and modulate the activity of proteins involved in both maintaining homeostatic conditions and protecting cells in harsh environmental conditions.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1comparative disease summarysupports2019Source 1DOIPubMed

The review compares calcium-binding protein expression in hibernating nervous systems with platinum-induced neurotoxicity and Alzheimer's disease to identify similarities and differences relevant to neurodegenerative mechanisms.

Quoted textsource-backed
Finally, we compare the expression of CBPs in the hibernating nervous system with two different conditions of neurodegeneration, i.e., platinum-induced neurotoxicity and Alzheimer's disease, to highlight the similarities and differences and demonstrate the potential of hibernation to shed light into part of the molecular mechanisms behind neurodegenerative diseases.
Claim 2functional role summarysupports2019Source 1DOIPubMed

Calcium-binding proteins can influence and respond to Ca2+ transients and modulate proteins involved in homeostasis and cellular protection under harsh environmental conditions.

Quoted textsource-backed
Calcium-binding proteins (CBPs) can influence and react to Ca2+ transients and modulate the activity of proteins involved in both maintaining homeostatic conditions and protecting cells in harsh environmental conditions.
Claim 3review focus summarysupports2019Source 1DOIPubMed

The review focuses on changes in Ca2+ signaling and the detection and activity of calcium-binding proteins in nervous systems during hibernation, especially cytosolic Ca2+ buffers and calmodulin.

Quoted textsource-backed
In this review, we describe the known changes in Ca2+-signaling and the detection and activity of CBPs in the nervous system of vertebrate and invertebrate models during hibernation, focusing on cytosolic Ca2+ buffers and calmodulin.