Back to first-pass browser

First-pass extracted concept

calcium imaging

Candidate: concept label2 source documents2 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Extracted Explainers

What the tool is doing

The paper uses calcium imaging to measure calcium conduction velocity and intracellular calcium transients in the setting of MYOM1 deficiency. It serves as a functional readout of sarcoplasmic reticulum-related calcium handling.

Source 1DOIPubMed

Resources required

The abstract indicates a calcium imaging workflow but does not specify reporters, dyes, or instrumentation.

Source 1DOIPubMed

What problem it solves

It helps connect molecular changes in sarcoplasmic reticulum regulators to functional calcium-handling defects.

Source 1DOIPubMed

What it does not solve

It does not alone establish whether the calcium defect is directly caused by reduced RYR2, SERCA2, or another upstream change.

Source 1DOIPubMed

Alternatives

The abstract complements calcium imaging with optical mapping, transcriptomics, immunoblotting, and structural phenotyping.

Source 1DOIPubMed

Evidence Snippets

Calcium imaging documented impaired calcium conduction velocity and blunted intracellular calcium transients, indicating sarcoplasmic reticulum dysfunction.
Evidence 1Source 1DOIPubMedprovenance
Optical transparency during development allows for the use of optogenetics and calcium imaging to elucidate the mechanisms underlying GI-related symptoms associated with ASD.
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1assay findingsupports2026Source 1DOIPubMed

Calcium imaging showed impaired calcium conduction velocity and blunted intracellular calcium transients, consistent with sarcoplasmic reticulum dysfunction, in MYOM1 deficiency.

Quoted textsource-backed
Calcium imaging documented impaired calcium conduction velocity and blunted intracellular calcium transients, indicating sarcoplasmic reticulum dysfunction.
Claim 2method enabling claimsupports2025Source 2DOIPubMed

Optical transparency during zebrafish development allows the use of optogenetics and calcium imaging to elucidate mechanisms underlying GI-related symptoms associated with ASD.