First-pass extracted concept

calcium-permeable AMPA receptors

Candidate: concept label1 source documents3 linked claims

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Aliases

CP-AMPARs, CPARs, GluA2-lacking, calcium-permeable AMPARs

Evidence Snippets

One important common adaptation is a shift in AMPAR subunit composition from GluA2-containing, calcium-impermeable AMPARs (CIARs) to GluA2-lacking, calcium-permeable AMPARs (CPARs).

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2018Handbook of experimental pharmacologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1biophysical propertysupports2018Source 1DOI PubMed

Compared with CIARs, CPARs have greater single-channel currents, faster activation kinetics, faster inactivation, and calcium-related activity, which has the potential to facilitate AMPAR currents.

Claim 2mechanistic summarysupports2018Source 1DOI PubMed

A common adaptation is a shift in AMPAR subunit composition from GluA2-containing calcium-impermeable receptors to GluA2-lacking calcium-permeable receptors.

Claim 3mechanistic summarysupports2018Source 1DOI PubMed

Alcohol-related adaptations in ionotropic glutamate receptors could promote excessive alcohol consumption even after long-term abstinence.