Calmodulin is singled out as a major focus in the review's discussion of Ca2+ signaling during hibernation. It is treated as part of the molecular machinery associated with neural adaptation and protection.
First-pass extracted concept
calmodulin
Candidate: concept label3 source documents5 linked claims
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Aliases
CaM
Extracted Explainers
What the tool is doing
What problem it solves
It helps anchor the review's discussion of how calcium-responsive proteins may participate in hypometabolic neuroprotection.
It addresses the need to convert transient Ca2+ fluctuations into actionable downstream signaling outputs.
It contributes to coupling Ca2+ signals to appropriate cellular responses.
What it does not solve
The abstract does not establish calmodulin as a standalone toolkit item or describe how to deploy it experimentally from this review alone.
The abstract does not indicate that CaM alone explains all plant calcium decoding or long-distance propagation behavior.
The abstract does not describe a specific calmodulin-based reagent, assay, or engineered platform.
Alternatives
The review contrasts calmodulin-focused discussion with broader cytosolic Ca2+ buffers and cytoskeletal-associated mechanisms.
The abstract names CMLs, CDPKs, and CBLs as other plant calcium-sensing or decoding systems.
The abstract lists calcineurin B-like proteins and calcium-dependent protein kinases as other Ca2+ sensor/decoder families.
Evidence Snippets
In this review, we describe the known changes in Ca2+-signaling and the detection and activity of CBPs in the nervous system of vertebrate and invertebrate models during hibernation, focusing on cytosolic Ca2+ buffers and calmodulin.
The occurrence in plants of calmodulin (CaM) ... indicate that plants possess specific tools and machineries to convert Ca2+ signals into appropriate responses.
characterizing the cellular [Ca2+]cyt-sensors (such as calmodulin, calcineurin B-like proteins and calcium-dependent protein kinases)
Supporting Sources
Linked Claims
The review focuses on changes in Ca2+ signaling and the detection and activity of calcium-binding proteins in nervous systems during hibernation, especially cytosolic Ca2+ buffers and calmodulin.
Quoted textsource-backed
In this review, we describe the known changes in Ca2+-signaling and the detection and activity of CBPs in the nervous system of vertebrate and invertebrate models during hibernation, focusing on cytosolic Ca2+ buffers and calmodulin.
CaM, CMLs, CDPKs, and CBLs are presented as plant calcium-sensing or decoding machineries that convert Ca2+ signals into appropriate responses.
Conversion of Ca2+ signals into biological responses requires Ca2+ sensors for decoding and relaying.
The review presents contributions of CaM/CMLs and CDPKs in plant immune responses against bacteria, fungi, viruses, and insects.
Calmodulin, calcineurin B-like proteins, and calcium-dependent protein kinases are presented as cellular Ca2+ sensors that allow plant cells to respond appropriately to cytosolic Ca2+ signals.
Quoted textsource-backed
characterizing the cellular [Ca2+]cyt-sensors (such as calmodulin, calcineurin B-like proteins and calcium-dependent protein kinases) that allow plant cells to respond appropriately to [Ca2+]cyt signals