Interactions between the cellular and structural components of the TME allow cancer cells to become invasive and disseminate from the primary site to distant locations, through a complex and multistep metastatic cascade.
First-pass extracted concept
cancer metastasis
Candidate: concept label1 source documents3 linked claims
Live refresh every 5sNext refresh in 5s
Evidence Snippets
Supporting Sources
Linked Claims
Hypoxic conditions at the primary tumor force cancer cells to genetically or epigenetically adapt in order to survive and metastasize.
Interactions between cellular and structural components of the tumor microenvironment enable cancer cell invasion and dissemination through a multistep metastatic cascade.
In the circulation, platelets, immune cells, and cytokines in the blood microenvironment facilitate cancer cell survival and transit.