Cancer neuroscience is presented as a research field focused on decoding communication between tumors and the nervous system. The review frames it as a route toward precision cancer therapies.
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cancer neuroscience
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The expanding field of cancer neuroscience seeks to unravel the essential signaling factors that drive the complex communication between cancer and the nervous system, utilizing these findings to enhance precision therapies for cancer management.
Progress in cancer neuroscience may create an important new pillar of cancer therapy.
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The nervous system is presented as a pivotal regulator of oncogenesis within the tumor microenvironment.
Neural-tumor crosstalk is described as operating through paracrine signaling, electrophysiological interactions, and structural innervation guided by axon-derived guidance molecules.
Neural-tumor interactions are described as driving cancer initiation, stemness maintenance, metabolic reprogramming, and therapeutic evasion.
Tumors are described as actively recruiting and remodeling local neurons by hijacking neurodevelopmental pathways to foster invasive growth.
Therapeutic strategies rooted in neural-tumor interactions are proposed as potentially synergistic with conventional standard treatments for refractory malignancies.
The review states that nervous system-cancer interactions can regulate oncogenesis, tumor growth, invasion, metastatic spread, treatment resistance, tumor-promoting inflammation, and anti-cancer immunity impairment.
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Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity.
The review states that nervous system-cancer interactions also act indirectly through effects on immune cells and stromal cells in the tumor microenvironment.
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as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment
The review states that neurons and cancer cells can communicate through direct paracrine and electrochemical mechanisms.
Quoted textsource-backed
Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells
The review proposes that progress in cancer neuroscience may become an important new pillar of cancer therapy.
Quoted textsource-backed
Progress in cancer neuroscience may create an important new pillar of cancer therapy.