This review considers existing modern approaches aimed to overcome both pre-existing natural immunity and immunity obtained after the administration of a gene therapy drug, which include various modifications of the viral drug (capsid modification, codon optimization)...
First-pass extracted concept
capsid modification
Candidate: concept label2 source documents2 linked claims
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Aliases
chemical conjugation, directed evolution, rational design
Evidence Snippets
Innovations in AAV engineering, such as capsid modification (chemical conjugation, rational design, directed evolution) ... enhance muscle tropism while mitigating immunogenicity and off-target effects.
Supporting Sources
Linked Claims
AAV engineering innovations including capsid modification, self-complementary genomes, and tissue-specific promoters such as MHCK7 enhance muscle tropism while mitigating immunogenicity and off-target effects.
Quoted textsource-backed
Innovations in AAV engineering, such as capsid modification (chemical conjugation, rational design, directed evolution), self-complementary genomes, and tissue-specific promoters (e.g., MHCK7), enhance muscle tropism while mitigating immunogenicity and off-target effects.
The review identifies capsid modification, codon optimization, empty capsid traps, corticosteroids, immune response inhibitors, nanoparticles, and IgG-degrading enzymes as approaches to overcome pre-existing and post-administration AAV immunity.