Beyond CAR-T cells, a growing cadre of MHC-independent effectors, including NK cells, macrophages, γδ T cells and the emerging innate-like T cells such as invariant NKT (iNKT) and mucosal-associated invariant T (MAIT) cells, offer complementary mechanisms for tumor recognition and elimination.
First-pass extracted concept
CAR-engineered innate immune cells
Candidate: concept label1 source documents4 linked claims
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Aliases
CAR-engineered innate and innate-like immune cells
Evidence Snippets
Supporting Sources
Linked Claims
Integrating innate and innate-like programs with precision CAR architectures is argued to enable universal, resilient cellular therapeutics with broadened antigen reach, improved safety profiles, and enhanced capacity to overcome the suppressive tumor microenvironment.
Quoted textsource-backed
We argue that integrating innate and innate-like programs with precision CAR architectures will yield a new generation of universal, resilient cellular therapeutics with broadened antigen reach, improved safety profiles, and enhanced capacity to overcome the suppressive tumor microenvironment.
Innate and innate-like CAR cell platforms are described as supporting off-the-shelf manufacture from healthy donors with low graft-versus-host disease risk and reduced propensity for severe cytokine release syndromes.
Quoted textsource-backed
These platforms combine facile, off-the-shelf manufacture from healthy donors with low graft-versus-host disease risk and a reduced propensity for severe cytokine release syndromes.
CAR engineering of innate and innate-like immune cells is positioned to confront heterogeneous and immune-evasive tumors by leveraging innate rapidity, innate-adaptive cross-talk, and distinctive homing.
Quoted textsource-backed
CAR engineering of these cells leverages their innate rapidity, innate/adaptive cross-talk, and distinctive homing to confront heterogeneous and immune-evasive tumors.
CAR-engineered innate and innate-like immune cell platforms provide complementary mechanisms for tumor recognition and elimination beyond CAR-T cells.
Quoted textsource-backed
Beyond CAR-T cells, a growing cadre of MHC-independent effectors, including NK cells, macrophages, γδ T cells and the emerging innate-like T cells such as invariant NKT (iNKT) and mucosal-associated invariant T (MAIT) cells, offer complementary mechanisms for tumor recognition and elimination.