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First-pass extracted concept

carbonic anhydrase IX

Candidate: concept label1 source documents3 linked claims
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Aliases

CAIX

Evidence Snippets

Many inhibitors have been discovered to target hypoxia-induced carbonic anhydrase IX (CAIX) due to its critical role in lung cancers.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1expression changesupports2026Source 1DOIPubMed

C1 downregulates CAIX and increases BAX and BAD mRNA in A549 cells.

Claim 2in silico resultsupports2026Source 1DOIPubMed

Docking and MD simulations support stable binding of C1 to CAIX.

Claim 3mechanismsupports2026Source 1DOIPubMed

The marine-derived compound C1 binds CAIX at sites distinct from current inhibitors.