First-pass extracted concept

cardiac neuromodulation

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

Promising new targets for cardiac neuromodulation include inhibitory and excitatory G-protein coupled receptors, neuropeptides, chemorepellents/attractants as well as the vagal and sympathetic nuclei in the central nervous system.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2024MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease mechanismsupports2024Source 1DOI PubMed

Ventricular arrhythmias in cardiac channelopathies are linked to autonomic triggers.

Claim 2future therapeutic strategysupports2024Source 1DOI PubMed

Improved molecular understanding of cardiac channelopathies and cellular autonomic signalling could refine autonomic therapies toward etiology-specific signalling pathways and central nervous system centers involved in cardiac autonomic regulation.

Claim 3target identificationsupports2024Source 1DOI PubMed

Promising new targets for cardiac neuromodulation include inhibitory and excitatory G-protein coupled receptors, neuropeptides, chemorepellents/attractants, and vagal and sympathetic nuclei in the central nervous system.

Claim 4therapeutic gapsupports2024Source 1DOI PubMed

Autonomic triggers in cardiac channelopathies are sub-optimally targeted by current management strategies.