We demonstrate that MuVLPs can be loaded with diverse payloads, including EGFP, Cre and Cas9/sgRNA ribonucleoproteins (Cas9 RNPs).
First-pass extracted concept
Cas9/sgRNA ribonucleoproteins
Candidate: concept label1 source documents4 linked claims
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Aliases
Cas9 RNPs
Evidence Snippets
Supporting Sources
Linked Claims
Treated mice showed significantly increased exercise capacity and endurance after MuVLP-mediated Cas9 RNP treatment.
Quoted textsource-backed
As a result, the treated mice exhibit a significantly increased capacity for exercise and endurance.
MuVLPs can be loaded with EGFP, Cre, and Cas9/sgRNA ribonucleoproteins and delivered into skeletal muscle cells via targeted membrane fusion.
Quoted textsource-backed
We demonstrate that MuVLPs can be loaded with diverse payloads, including EGFP, Cre and Cas9/sgRNA ribonucleoproteins (Cas9 RNPs), and can be delivered into skeletal muscle cells via targeted membrane fusion.
MuVLP-mediated Cas9 RNP treatment restored dystrophin expression in multiple skeletal muscle tissues in the DMD mouse model.
Quoted textsource-backed
This treatment restores dystrophin expression in various skeletal muscle tissues, including the diaphragm, quadriceps, tibialis anterior, gastrocnemius, and triceps.
Systemically administered MuVLPs carrying Cas9 RNPs enabled skeletal muscle-specific gene editing that excised a premature-terminator-containing exon in a DMD mouse model.
Quoted textsource-backed
Systemic administration of MuVLPs carrying Cas9 RNPs enables skeletal muscle-specific gene editing, which excised the exon containing a premature terminator codon mutation in a mouse model for Duchenne muscular dystrophy (DMD).