First-pass extracted concept

cat B-mitochondrial apoptotic pathway

Candidate: concept label1 source documents3 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

cathepsin B-mitochondrial apoptotic pathway

Evidence Snippets

The present data demonstrate that a cat B-mitochondrial apoptotic pathway plays a pivotal role in TNF-alpha-induced hepatocyte apoptosis and liver injury.

Evidence 1Source 1DOIprovenance

Supporting Sources

Source 1primary paper2001American Journal Of PathologyDOI

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1genetic perturbation effectsupports2001Source 1DOI

Cathepsin B knockout mice show less TNF-alpha-induced hepatocyte apoptosis, no detectable cytochrome c release, and no detectable caspase 9 or 3 activation compared with wild-type mice in the sensitized liver injury model.

Claim 2mechanistic rolesupports2001Source 1DOI

A cathepsin B-mitochondrial apoptotic pathway plays a pivotal role in TNF-alpha-induced hepatocyte apoptosis and liver injury.

Claim 3survival effectsupports2001Source 1DOI

After TNF-alpha injection, survival at 4 hours was higher in cathepsin B knockout mice than in wild-type mice in the sensitized liver injury model.