excitation of caudal glutamatergic PPN neurons can normalize the otherwise severe locomotor deficit in PD
First-pass extracted concept
caudal glutamatergic pedunculopontine nucleus neurons
Candidate: concept label1 source documents4 linked claims
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Aliases
caudal glutamatergic PPN neurons
Evidence Snippets
Supporting Sources
Linked Claims
In vivo cell-type-specific activation of caudal glutamatergic PPN neurons restores or normalizes severe locomotor deficits in two mouse models of parkinsonism caused by acute pharmacological blockade of dopamine transmission.
Quoted textsource-backed
Here, we use in vivo cell-type specific PPN activation to restore motor function in two mouse models of parkinsonism made by acute pharmacological blockage of dopamine transmission. With a combination of chemo- and opto-genetics, we show that excitation of caudal glutamatergic PPN neurons can normalize the otherwise severe locomotor deficit in PD
The pedunculopontine nucleus contains glutamatergic neurons that control locomotor initiation and maintenance.
Quoted textsource-backed
The pedunculopontine nucleus (PPN) is a locomotor command area containing glutamatergic neurons that control locomotor initiation and maintenance.
Motor rescue driven by glutamatergic PPN activation is independent of activity in nearby locomotor-promoting glutamatergic cuneiform neurons.
Quoted textsource-backed
The motor rescue driven by glutamatergic PPN activation is independent of activity in nearby locomotor promoting glutamatergic Cuneiform neurons.
Caudal glutamatergic PPN neurons are a potential target for neuromodulatory restoration of locomotor function in Parkinson's disease.
Quoted textsource-backed
Our observations point to caudal glutamatergic PPN neurons as a potential target for neuromodulatory restoration of locomotor function in PD.