First-pass extracted concept

caveolae

Candidate: concept label2 source documents7 linked claims

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Evidence Snippets

Unsupervised clustering identified ... only in CAVIN1-expressing cells, spherical, hollow caveolae.

In many different cell types, the plasma membrane is heavily decorated with small pits of 60–80 nm in diameter, which constitute a specialized type of microdomain called caveolae.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2018Scientific ReportsDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2010Journal of Cell ScienceDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1assembly modelsupports2018Source 1DOI PubMed

Multi-threshold modularity analysis suggests that S1A scaffolds interact to form larger scaffolds and that S1A dimers group together in the presence of CAVIN1 to form the caveolae coat.

Quoted textsource-backed

Multi-threshold modularity analysis suggests that S1A scaffolds interact to form larger scaffolds and that S1A dimers group together, in the presence of CAVIN1, to form the caveolae coat.

Claim 2condition specific structuresupports2018Source 1DOI PubMed

Spherical hollow caveolae were identified only in CAVIN1-expressing cells.

Quoted textsource-backed

only in CAVIN1-expressing cells, spherical, hollow caveolae

Claim 3component requirementsupports2010Source 2DOI PubMed

Caveolin expression induces and is required for caveola formation.

Quoted textsource-backed

the subsequent demonstration that caveolin expression induces, and is required for, the formation of caveolae

Claim 4component requirementsupports2010Source 2DOI PubMed

Cavin-1/PTRF is an essential factor required for stabilization of caveolae at the plasma membrane.

Quoted textsource-backed

cavin-1 (also known as polymerase I and transcript release factor, PTRF) ... as an essential factor required for the stabilization of caveolae at the plasma membrane

Claim 5evidence caveatmixed2010Source 2DOI PubMed

Many proposed caveola-associated signaling interactions require confirmation with independent techniques and should distinguish caveolar from non-caveolar caveolin pools.

Quoted textsource-backed

many of these interactions need to be confirmed by using independent techniques ... In addition, roles for caveolar and non-caveolar pools of caveolin must be considered

Claim 6function summarysupports2010Source 2DOI PubMed

Caveolae have been implicated in endocytosis, cholesterol and lipid metabolism, mechanosensation, and cellular signaling.

Quoted textsource-backed

Caveolae have been implicated in endocytosis, cholesterol and lipid metabolism, mechanosensation and cellular signaling.

Claim 7mechanism summarysupports2010Source 2DOI PubMed

Stabilization of caveolae by the cavin complex is proposed to arise from multiple weak phosphatidylserine-cavin interactions consistent with coincidence detection.

Quoted textsource-backed

the stabilisation of caveolae by the cavin complex could be the result of the sum of the many – but relatively weak – binding interactions between PtSer and cavin molecules. Such a mechanism, termed coincidence detection