The essential role of a newly characterized multi-protein complex – the cavin complex – for caveola formation at the plasma membrane has been highlighted in the past few years.
First-pass extracted concept
cavin complex
Candidate: concept label1 source documents3 linked claims
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Linked Claims
Cavin-1/PTRF is an essential factor required for stabilization of caveolae at the plasma membrane.
Quoted textsource-backed
cavin-1 (also known as polymerase I and transcript release factor, PTRF) ... as an essential factor required for the stabilization of caveolae at the plasma membrane
Stabilization of caveolae by the cavin complex is proposed to arise from multiple weak phosphatidylserine-cavin interactions consistent with coincidence detection.
Quoted textsource-backed
the stabilisation of caveolae by the cavin complex could be the result of the sum of the many – but relatively weak – binding interactions between PtSer and cavin molecules. Such a mechanism, termed coincidence detection
The cavin complex is recruited to the plasma membrane in a cavin-1-dependent fashion by caveolin and does not associate with the Golgi pool of caveolin.
Quoted textsource-backed
The cavin complex ... is recruited to the plasma membrane in a cavin-1-dependent fashion by caveolin ... but does not associate with the pool of caveolin in the Golgi complex