First-pass extracted concept

CCK-expressing NTS neurons

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Aliases

CCK NTS neurons

Evidence Snippets

Here we identify cholecystokinin (CCK) and noradrenergic, dopamine β-hydroxylase (DBH)-expressing NTS neurons as two separate populations that directly excite CGRP(PBN) neurons.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2016Nature CommunicationsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional effectsupports2016Source 1DOI PubMed

Activation of CCK-expressing and DBH-expressing NTS neurons using optogenetic or chemogenetic methods decreases food intake.

Quoted textsource-backed

When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases

Claim 2functional effectsupports2016Source 1DOI PubMed

Chronic stimulation of these NTS neuron populations causes mice to lose body weight.

Quoted textsource-backed

with chronic stimulation mice lose body weight

Claim 3mechanistic relationshipsupports2016Source 1DOI PubMed

CCK-expressing NTS neurons directly excite CGRP-expressing PBN neurons.

Quoted textsource-backed

Here we identify cholecystokinin (CCK) ... NTS neurons as two separate populations that directly excite CGRP(PBN) neurons.

Claim 4mechanistic relationshipsupports2016Source 1DOI PubMed

Optogenetic results indicate that CCK and DBH neurons in the NTS directly engage CGRP-expressing PBN neurons to promote anorexia.

Quoted textsource-backed

Our optogenetic results reveal that CCK and DBH neurons in the NTS directly engage CGRP(PBN) neurons to promote anorexia.