First-pass extracted concept

CeA→BNST CRF-dependent pathway

Candidate: concept label1 source documents3 linked claims

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Aliases

central amygdala to bed nucleus of the stria terminalis projection, CRF-dependent amygdalofugal pathway

Evidence Snippets

The paper shows that ... optogenetic inhibition of CeA CRF neurons, specifically the CeA→BNST projection, reverses escalated alcohol drinking and some withdrawal signs in dependent rats.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019Nature CommunicationsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanism inferencesupports2019Source 1DOI PubMed

The study implicates CRF-CRF1 signaling in the CeA→BNST pathway logic relevant to alcohol dependence.

Claim 2mechanistic rolesupports2019Source 1DOI PubMed

Alcohol-withdrawal recruitment of a central amygdala neuronal ensemble is heavily enriched for CRF neurons.

Claim 3projection specific effectsupports2019Source 1DOI PubMed

Optogenetic inhibition of the CeA→BNST projection reverses escalated alcohol drinking and some withdrawal signs in dependent rats.