First-pass extracted concept

CeA-LPB pathway

Candidate: concept label1 source documents4 linked claims

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Aliases

amygdalo-parabrachial pathway

Extracted Explainers

What the tool is doing

The paper describes the CeA-LPB pathway as an inhibitory amygdalo-parabrachial circuit that regulates pain-related activity in parabrachial neurons. Its efficacy is reported to be suppressed in chronic pain.

Source 1DOI PubMed

What problem it solves

This concept helps explain a circuit mechanism linking central amygdala inhibition to pain perception and chronic pain pathogenesis.

Source 1DOI PubMed

What it does not solve

The abstract does not establish this pathway as a standalone toolkit item or provide implementation details for using it as an experimental tool.

Source 1DOI PubMed

Alternatives

The abstract contrasts pathway stimulation versus pathway inhibition as opposite manipulations of the same circuit, but does not name alternative circuit targets.

Source 1DOI PubMed

Evidence Snippets

We find that the efficacy of this CeA-LPB pathway is suppressed in chronic pain. Further, optogenetically stimulating this pathway suppresses acute pain, and inhibiting it, in naive animals, evokes pain behaviors.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2020Journal of NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1causal perturbationsupports2020Source 1DOI PubMed

Optogenetic stimulation of the CeA-LPB pathway suppresses acute pain, whereas inhibition of this pathway in naive animals evokes pain behaviors.

Quoted textsource-backed

Further, optogenetically stimulating this pathway suppresses acute pain, and inhibiting it, in naive animals, evokes pain behaviors.

Claim 2circuit anatomysupports2020Source 1DOI PubMed

In rats and mice, LPB contains few GABAergic neurons and most of its GABAergic inputs arise from CeA neurons expressing dynorphin, somatostatin, and/or corticotropin releasing hormone.

Quoted textsource-backed

We show that, in both rats and mice, LPB contains few GABAergic neurons, and that most of its GABAergic inputs arise from CeA. These CeA GABA neurons express dynorphin, somatostatin, and/or corticotropin releasing hormone.

Claim 3mechanistic rolesupports2020Source 1DOI PubMed

Chronic pain is associated with amplified activity of parabrachial neurons in mice and this amplification is related to suppressed inhibition from CeA to LPB neurons.

Quoted textsource-backed

Here we demonstrate that similar activity amplification occurs in mice, and that this is related to suppressed inhibition to lateral parabrachial (LPB) neurons from the CeA in animals of either sex.

Claim 4pathogenesissupports2020Source 1DOI PubMed

The CeA-LPB pathway is critically involved in pain regulation and in the pathogenesis of chronic pain.

Quoted textsource-backed

These findings demonstrate that the CeA-LPB pathway is critically involved in pain regulation, and in the pathogenesis of chronic pain.