This concept covers methods that inhibit cellular function in C. elegans rather than removing the cell. The abstract presents inhibition as a way to infer cell function from resulting changes in circuits, organismal function, or behavior.
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cell inhibition methods in Caenorhabditis elegans
Candidate: concept label1 source documents4 linked claims
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C. elegans cell ablation and inhibition approaches include constitutive and acute reversible methods, and can act systemically or locally.
Quoted textsource-backed
A range of approaches and tools were developed and used over the past few decades that act either constitutively or acutely and reversibly, in systemic or local fashion.
Inhibiting cellular function or removing a cell type can be used to understand the function of cells such as neurons by observing consequences on organismic function, circuit function, and behavior.
Quoted textsource-backed
To understand the function of cells such as neurons within an organism, it can be instrumental to inhibit cellular function, or to remove the cell (type) from the organism, and thus to observe the consequences on organismic and/or circuit function and animal behavior.
The reviewed C. elegans cell ablation and inhibition approaches use either drugs or genetically encoded tools, and some acute inhibitory tools require an exogenous trigger such as light.
Quoted textsource-backed
These approaches make use of either drugs or genetically encoded tools. Also, there are acutely acting inhibitory tools that require an exogenous trigger like light.
The paper reviews methods for cell ablation and cell inhibition developed and used in Caenorhabditis elegans.
Quoted textsource-backed
Here, we give an overview of such methods developed and used in the nematode Caenorhabditis elegans.