Dissection of cell signaling requires tools that can mimic spatiotemporal dynamics of individual pathways in living cells.
First-pass extracted concept
cell signaling
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During the last 100 years, cell signaling has evolved into a common mechanism for most physiological processes across systems.
Inductive Tissue Interactions, Cell Signaling, and the Control of Kidney Organogenesis
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Dissection of cell signaling requires tools that can mimic spatiotemporal dynamics of individual pathways in living cells.
Cell signaling is relayed from the membrane to the nucleus, where gene expression, translation, and protein targeting are triggered.
Quoted textsource-backed
The message is thus relayed from the membrane to the nucleus where gene expression ns, subsequent translations, and protein targeting to the cell membrane and other organelles are triggered.
Cellular messages are transferred from ligands to receptors and decoded through cascades of second messengers including kinases, phosphatases, GTPases, ions, and small molecules such as cAMP, cGMP, and diacylglycerol.
Quoted textsource-backed
Here, we review how the messages are transferred from the first messenger (the ligand) to the receptor, and then decoded with the help of cascades of second messengers (kinases, phosphatases, GTPases, ions, and small molecules such as cAMP, cGMP, diacylglycerol, etc.).
Directionality and distribution of signaling strength across pathways, including pathway crosstalk, help determine the amplitude and quality of final effector output.
Quoted textsource-backed
Other crucial parameters in cell signaling are its directionality and distribution of signaling strengths in different pathways that may crosstalk to adjust the amplitude and quality of the final effector output.
Specificity of ligand response profiles is generated by combinations of selected intracellular signaling intermediates despite a limited number of intracellular messengers.
Quoted textsource-backed
Although there are limited numbers of intracellular messengers, the specificity of the response profiles to the ligands is generated by the involvement of a combination of selected intracellular signaling intermediates.
Cell signaling is described as a common mechanism underlying most physiological processes across systems.
Quoted textsource-backed
During the last 100 years, cell signaling has evolved into a common mechanism for most physiological processes across systems.
This review synthesizes how inductive tissue interactions and cell signaling control kidney organogenesis.