Furthermore, we explore emerging strategies, including gene therapy, stem cell therapy, cell type-specific neuromodulation, and AI-driven techniques for objective, unbiased pain assessment and research.
First-pass extracted concept
cell type-specific neuromodulation
Candidate: concept label2 source documents6 linked claims
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Evidence Snippets
Yet growing evidence indicated the importance of cell-type-specific neuromodulation in the PNS in not only biological research using animal models but also potential human therapies.
Supporting Sources
Linked Claims
The review states that these innovative approaches are poised to enable discovery of safer and more effective analgesics.
Quoted textsource-backed
These innovative approaches are poised to revolutionize pain management, paving the way for the discovery of safer and more effective analgesics.
Opioid-dominated acute pain management is limited by addiction, tolerance, and dependence risks, motivating development of nonopioid analgesics.
Quoted textsource-backed
Acute pain management has historically been dominated by opioids, whose efficacy is overshadowed by the risks of addiction, tolerance, and dependence, culminating in the global opioid crisis. To transcend this issue, we must innovate beyond opioid-based μ receptor treatments, identifying nonopioid analgesics with high efficacy and minimal adverse effects.
Emerging nonopioid pain-management strategies discussed in the review include gene therapy, stem cell therapy, cell type-specific neuromodulation, and AI-driven techniques for objective unbiased pain assessment and research.
Quoted textsource-backed
Furthermore, we explore emerging strategies, including gene therapy, stem cell therapy, cell type-specific neuromodulation, and AI-driven techniques for objective, unbiased pain assessment and research.
Mechanism-based analgesic targets should be tailored to specific pain conditions including inflammatory, neuropathic, and nociplastic pain.
Quoted textsource-backed
This Review navigates the multifaceted landscape of inflammatory, neuropathic, and nociplastic pain, emphasizing mechanism-based analgesic targets tailored to specific pain conditions.
Conventional neuromodulatory approaches have revealed essential biological functions of the peripheral nervous system and provided tools to treat many human diseases, but the review positions optogenetics as addressing the need for cell-type-specific control.
Cell-type-specific neuromodulation is important in the peripheral nervous system for both animal-model research and potential human therapies.