First-pass extracted concept

central melanocortin system

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Evidence Snippets

the central melanocortin system plays a critical role in the regulation of energy homeostasis

Following the cloning of the melanocortin receptor and agouti protein genes, a model was developed for the central melanocortin system with respect to the regulation of energy and glucose homeostasis.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2016Journal of Molecular EndocrinologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Source 2review2015Journal of NeuroendocrinologyDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1biological rolesupports2016Source 1DOI PubMed

The central melanocortin system plays a critical role in regulation of energy homeostasis.

Claim 2disease associationsupports2016Source 1DOI PubMed

MC4R mutations are the most common cause of early onset syndromic obesity and account for 2-5% of all cases.

Claim 3review scopesupports2016Source 1DOI PubMed

α-MSH is described as the predominant melanocortin peptide in the CNS regulating feeding and energy homeostasis.

Claim 4review scope summarysupports2015Source 2DOI PubMed

The review states that advanced technologies including Cre-LoxP transgenic mouse technology, pharmacogenetics, and optogenetics produced paradigm shifts in understanding of the central melanocortin system over the last decade.

Claim 5system model summarysupports2015Source 2DOI PubMed

The review summarizes an earlier central melanocortin model in which leptin regulates melanocortin peptides and AgRP from POMC and AgRP neurons, and AgRP competitively antagonizes melanocortin peptide activation of MC4R linked to Gαs and cAMP signaling.