central nucleus of the amygdala (Ce)
First-pass extracted concept
central nucleus of the amygdala
Candidate: concept label1 source documents5 linked claims
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Ce
Evidence Snippets
Supporting Sources
Linked Claims
Anatomical studies indicate that the Ce and BST form a tightly interconnected unit that can integrate threat-relevant information to assemble states of fear and anxiety.
Quoted textsource-backed
Anatomical studies show that the Ce and BST form a tightly interconnected unit, where different kinds of threat-relevant information can be integrated and used to assemble states of fear and anxiety.
The paper argues against a strictly dissociable Ce-versus-BST model of phasic fear and sustained anxiety and instead supports viewing them as an integrated central extended amygdala unit.
Quoted textsource-backed
It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST)... However, new observations encourage a different perspective. Anatomical studies show that the Ce and BST form a tightly interconnected unit
Imaging studies in humans and monkeys show that the Ce and BST have similar functional profiles.
Quoted textsource-backed
Imaging studies in humans and monkeys show that the Ce and BST exhibit similar functional profiles.
Mechanistic studies demonstrate that both the Ce and BST can control the expression of fear and anxiety during sustained exposure to diffuse threat.
Quoted textsource-backed
Mechanistic studies demonstrate that both regions can control the expression of fear and anxiety during sustained exposure to diffuse threat.
Both the Ce and BST are sensitive to aversive challenges including uncertain or temporally remote threat, show phasic responses to short-lived threat, and show heightened activity during sustained exposure to diffusely threatening contexts.
Quoted textsource-backed
Both regions are sensitive to a range of aversive challenges, including uncertain or temporally remote threat; both covary with concurrent signs and symptoms of fear and anxiety; both show phasic responses to short-lived threat; and both show heightened activity during sustained exposure to diffusely threatening contexts.